| Player | Date | Interceptions | Yards Returned | Touchdown | Opponent |
| Wear Schoonover | 10/26/1929 | 6 | unknown | unknown | Texas A&M |
| Michael Grant | 10/28/2006 | 3 | 0 | 0 | LA. Monroe |
| David Hogue | 11/14/1970 | 3 | 20 | 0 | SMU |
| Louis Campbell | 12/20/1971 | 3 | 12 | 0 | Tennessee |
| Billy Moore | 11/18/1961 | 3 | 4 | 0 | SMU |
| Kay Eakin | 10/23/1937 | 3 | 0 | 0 | SMU |
| Rashaad Johnson | 10/27/2007 | 2 | 5 | 0 | Florida Int. |
| Matterral Richardson | 10/20/2007 | 2 | 1 | 0 | Ole Miss |
| Chris Houston | 11/18/2006 | 2 | 129 | 0 | Miss. State |
| Lerinezo Robbinson | 09/18/2004 | 2 | 29 | 0 | LA. Monroe |
| Bo Mosley | 11/22/2003 | 2 | 7 | 0 | Miss. State |
| Ken Hamlin | 11/16/2002 | 2 | 4 | 0 | LA. Lafayette |
| Lawrence Richardson | 11/23/2002 | 2 | 9 | 0 | Miss. State |
| Spencer Brown | 09/09/1995 | 2 | 7 | 0 | South Carolina |
| Dean Peevy | 11/27/1992 | 2 | -3 | 0 | LSU |
| Michael James | 10/12/1991 | 2 | 75 | 1 | Houston |
| Curtis Banks | 09/07/1991 | 2 | 13 | 0 | SMU |
| Patrick Williams | 10/22/1988 | 2 | 10 | 0 | Houston |
| Steve Atwatter | 12/05/1987 | 2 | 37 | 0 | Hawaii |
| Charles Washington | 10/25/1986 | 2 | 32 | 0 | Houston |
| Richard Brothers | 09/13/1986 | 2 | 17 | 0 | Ole Miss |
| Kevin Wyatt | 10/27/1984 | 2 | 14 | 0 | Houston |
| Kevin Evans | 11/22/1979 | 2 | 32 | 0 | SMU |
| Kevin Evans | 12/25/1978 | 2 | 12 | 0 | UCLA |
| Floyd Hogan | 09/14/1974 | 2 | 92 | 0 | USC |
| Louis Campbell | 10/14/1972 | 2 | unknown | 0 | Baylor |
| Louis Campbell | 10/02/1971 | 2 | 61 | 1 | TCU |
| Mike Davis | 10/09/1971 | 2 | unknown | 0 | Baylor |
| Louis Campbell | 11/06/1971 | 2 | unknown | 0 | Rice |
| Jerry Moore | 01/01/1969 | 2 | 4 | 0 | Georgia |
| Bobby Field | 11/27/1969 | 2 | 45 | 0 | Texas Tech |
| Jerry Moore | 11/23/1968 | 2 | unknown | 0 | Texas Tech |
| Tommy Dixon | 11/23/1968 | 2 | unknown | 0 | Texas Tech |
| Tommy Trantham | 11/11/1967 | 2 | 53 | 0 | Rice |
| Tommy Trantham | 11/06/1965 | 2 | 78 | 0 | Rice |
| Gerald Nesbitt | 11/17/1956 | 2 | 50 | 0 | SMU |